L-Tryptophan: Health Benefits, How to Take & Side Effects

L-tryptophan is an essential amino acid that is necessary for the production of serotonin, which is a neurotransmitter that regulates mood and sleep. Therefore, regulating L-tryptophan levels is important for preventing and managing depression, sleep disorders and anxiety.

Additionally, L-tryptophan can also be used for the management of pain, binge eating, stress, and hyperactivity in children.

L-tryptophan supplements can be purchased at drugstores and health food stores in capsule or powder form. They should only be taken as guided by a doctor or registered dietitian, as this supplement can cause side effects and is not recommended in some populations.

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Health benefits

L-tryptophan has several medicinal properties and can be indicated for:

  • Treating anxiety;
  • Managing childhood hyperactivity;
  • Reducing stress;
  • Managing depression;
  • Promoting weight loss;
  • Relieving pain, like cramps and headaches;
  • Regulating sleep.

Additionally, supplementing with L-tryptophan can also be beneficial for improving libido and blood clotting.

What is the difference between tryptophan and L-tryptophan?

Tryptophan is an essential amino acid that is naturally found in foods like cocoa, cheese, nuts and bananas. Read more about tryptophan and the foods it is naturally found in.

L-tryptophan is also an essential amino acid, but it is the chemical form of this nutrient and is only found in dietary supplements.

How to take

Dosing for L-tryptophan can vary depending on the type of supplement you are taking as well as your health goals. However, general guidelines for use of this supplement in adults are as follows:

  • L-tryptophan powder: 500 mg to 1g per day, which should be diluted in a glass of water and taken with meals;
  • L-tryptophan capsules: 1 to 6 g per day, with a glass of water, with meals.

It is important to remember that the dosage and treatment duration may vary depending on the objective to be treated, the type of supplement and the person's age, which is why L-tryptophan should be guided by a doctor or registered dietitian.

Possible side effects

Some of the most common side effects of L-tryptophan include nausea, dry mouth, loss of appetite, headache, drowsiness, dizziness, stomach pain, and diarrhea.

Taking large doses of L-tryptophan can also lead to agitation, mental confusion, tremors, and excessive sweating.

Contraindications for use

Pregnant or breastfeeding women should only take L-tryptophan as approved by their OBGYN, as its safety in these populations is not fully supported by scientific studies yet.  

Additionally, people who regularly use medications such as painkillers, antidepressants, antibiotics or medicinal plants such as St. John's wort or valerian should talk to their doctor before using L-tryptophan, as this supplement can intefere with the action of several medications.